The Transit-Pelletsmethod™ provides information on total and segmental transit time as well as normal and slow transit. With the new modification of the marker intake on day six, it is possible to also easily measure rapid transit, which may be of interest in the investigation of chronic diarrhoea. The method requires only one hospital visit, takes into account women’s slower transit, and is also suitable for children and teenagers. Transit-Pelletsmethod™, commonly known as the ‘Abrahamsson Method’, has been described in several research papers in international journals. The method is applied and continuously developed in ongoing clinical trials at Sahlgrenska University Hospital.
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A simple and effective method
Colonic transit test with radiopaque markers (Transit-Pellets™) is a useful diagnostic measurement in the investigation and assessment of many gastrointestinal (GI) disorders such as:
- Chronic Constipation
- Chronic Diarrhoea
- Constipation dominated Irritable Bowel Syndrome (IBS-C)
- Diarrhoea dominated Irritable Bowel Syndrome (IBS-D)
- Colonic Inertia
- Outlet Obstruction
The patient swallows radiopaque markers for 6 consecutive days. On day 7 an abdominal radiograph is taken. Based on the number of retained markers and their position in the colon a colonic transit time is calculated and compared to reference values. Because only one radiograph is needed the radiation dose is limited and the cost for the test kept at a minimum.
Measure rapid, normal and slow colonic transit
The most common reason to do this investigation is suspicion of slow-transit constipation. With the new modification of marker intake on the sixth day it is also possible to easily measure rapid passage, which could be of interest in the investigation of patients with chronic diarrhoea.
The Advantages of Transit-Pellets™ and the Transit-Pelletsmethod™
- Helps the physician to understand the patient’s problem and to make further decision on treatment
- A cost effective alternative to expensive methods like wireless capsules and scintigraphy
- Provides information about total and segmental transit time
- The method is validated and has been used in several thousand patients
- Only one X-ray needed
- Take’s women’s slower colonic transit times into account
- Also suitable for children and teenagers
- Gives a mean value for several days’ markers
- Can measure slow, normal and rapid colonic transit
The Transit-Pelletsmethod™ method was developed at Sahlgrenska University Hospital, Sweden, and is documented in more than twenty scientific reports, examples shown below.
Gastrointestinal and colonic segmental transit time evaluated by a single abdominal x-ray in healthy subjects and constipated patients. Abrahamsson H, Antov S, Bosaeus I. Scand J Gastroenterol. 1988;Suppl 152:72- 80. This original study showed the usefulness of the Transit-Pellets™ method with intake of 10 markers daily for 6 days followed by an abdominal X-ray on day 7. Based on the principle that an equilibrium between ingested and excreted markers has been attained at X-ray. Click here
Accuracy in assessment of colonic transit time with particles: how many markers should be used? Abrahamsson H, Antov S. Neurogastroenterol Motil. 2010;22:1164-69. Showed that measurement of colonic transit time with 10 markers daily yields an accuracy very similar to 15-20 markers daily but a significantly higher accuracy than 5 markers daily. Click here
Gender differences in gut transit shown with a newly developed radiological procedure. Sadik R, Abrahamsson H, Stotzer PO. Scand J Gastroenterol. 2003;38:36-42. This study showed that modification of the Transit-Pellets™ method by dividing the marker dose on day 6 into one morning dose and one evening dose is a simple and safe principle to measure rapid, normal and slow colonic transit. Click here
Colonic transit time and IBS symptoms: what’s the link? Törnblom H, Van Oudenhove L, Sadik R, Abrahamsson H, Tack J, Simrén M. Am J Gastroenterol. 2012;107:754-60. Study on a large number of patients showing that the modified Transit-Pellets™ method is very useful to characterize e.g. IBS patients with respect to normal, slow or rapid colonic transit. Click here
Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption. Sadik R, Abrahamsson H, Ung KA, Stotzer PO. Am J Gastroenterol. 2004;99:711-8. Transit-Pellets™ method can be used to elucidate pathophysiology and diagnosis in patients with rapid colonic transit. In this study demonstrated in the diarrhoeal disease bile acid malabsorption. Click here
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